A sliding door system (105) includes a track assembly (120) and a door (125) slidably connected to the track. Seals (245, 250, 605, 610, 300, 500) disposed about the door limit sound and/or infectious materials from passing thereby. One or more of the seals (245, 250) are disposed between the door and the track assembly. One or more other seals (605, 610) are disposed between the door and a wall to seal around the trailing end of the door. The system may also include a door dock (130) with one or more seals (300, 500) to seal around the leading end of the door. The system can also include a drop seal assembly (700) that selectively seals off a gap between the bottom of the door and the floor.