A rotary screw compressor includes a compressor assembly and a drive motor assembly. The compressor assembly includes a compressor housing, a first screw rotor and a second screw rotor installed in the compressor housing and engaged with each other. An end of the first screw rotor is an engaging end. The drive motor assembly includes a motor housing, a motor rotor, a motor stator and a centering bushing installed in the motor housing, and the motor stator installed on an outer side of the motor rotor and capable of driving the motor rotor to rotate, and the centering bushing is passed and connected to the inner circumference of the motor rotor and has an end sheathed on the engaging end, so that the motor rotor can drive the first screw rotor to rotate through the centering bushing and the engaging end.