A touch substrate and a display panel are disclosed. The touch substrate includes a touch region and a binding region, and the touch substrate includes a plurality of first touch electrodes and a plurality of first lead wires. The plurality of the first touch electrodes are located on the touch region. The plurality of the first touch electrodes are sequentially arranged along the first direction. One end of each of the plurality of the first lead wires is connected to one of the plurality of the first touch electrodes one by one, and another end of each of the plurality of the first lead wires is connected to the binding region. Further, at least one of the plurality of the first lead wires is located in the touch region.