The present invention is directed to systems for interfacing between sensors and sensor simulators and clinical monitors and devices. The present invention is used to incorporate sensors and sensor simulators into training and clinical demonstrations. A system in accordance with the present invention includes a hardware component configured to transmit an output signal associated with a typical clinical sensor such as sensors for end-tidal CO2 pulse oximetry, temperature, blood pressure, near-infrared spectroscopy (NIRS) sensors, and CPR sensors to a clinical monitor or similar device. The system of the present invention also provides a software component to produce and transmit or to receive and make use of the simulated or actual sensor; the system also provides a hardware component to interface the software component to the clinical monitor, defibrillator, and/or sensor.