A power supply apparatus wake-up circuit is provided. The power supply apparatus wake-up circuit includes a power consumption control circuit and a wake-up circuit connected to the power consumption control circuit. The power consumption control circuit includes a voltage regulation module and a protection circuit connected to the voltage regulation module. The voltage regulation module adjusts a voltage output to the protection circuit according to a sleep control signal. The protection circuit determines whether to trigger over-discharge protection according to an input voltage. The wake-up circuit includes a first switching device, and the wake-up circuit outputs a wake-up control signal to the protection circuit based on an operation of the first switching device by a user such that the protection circuit stops triggering the over-discharge protection.