Various implementations include systems for processing inner microphone audio signals. In particular implementations, a system includes an external microphone configured to be acoustically coupled to an environment outside an ear canal of a user; an inner microphone configured to be acoustically coupled to an environment inside the ear canal of the user; and an adaptive noise cancelation system configured to process an internal signal captured by the inner microphone and generate a noise reduced internal signal, wherein the noise reduced internal signal is adaptively generated in response to an external signal captured by the external microphone.