Invention Grant
- Patent Title: PTP4A1 as a therapeutic target for fibrotic diseases and disorders including systemic sclerosis
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Application No.: US15257587Application Date: 2016-09-06
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Publication No.: US11331388B1Publication Date: 2022-05-17
- Inventor: Nunzio Bottini , Cristiano Sacchetti , Stephanie M. Stanford
- Applicant: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
- Applicant Address: US CO La Jolla
- Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
- Current Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
- Current Assignee Address: US CO La Jolla
- Agency: Pillsbury Winthrop Shaw Pittman LLP
- Main IPC: C07K16/40
- IPC: C07K16/40 ; A61K38/46 ; C12N15/113 ; C12N15/86 ; C12Q1/6883 ; A61K45/06 ; G01N33/68 ; A01K67/027
Abstract:
Methods of treating fibrotic diseases and disorders including Systemic sclerosis (SSc) are provided. Methods include, for example, administering to a subject an effective amount of an antagonist/inhibitor of PTP4A1 protein expression or activity to treat a fibrotic disease or disorder such as SSc, or an associated pathology such as organ or skin fibrosis.
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