A method of making a treatment plan with a treatment planning system and radiotherapy system are provided. The method includes: acquiring a preset dose distribution scheme; generating at least one radiation dose distribution scheme to be used with the treatment planning system, wherein the treatment plan system is adapted to at least one of beam energy of the radiotherapy system, a size of a collimator of the radiotherapy system, a radiation angle and radiation time of the radiotherapy system; and comparing the at least one radiation dose distribution scheme to be used with the preset dose distribution scheme, and determining, among the at least one radiation dose distribution scheme, a radiation dose distribution scheme that is the closest to the preset dose distribution scheme to make the treatment plan.