Invention Grant
- Patent Title: Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors
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Application No.: US17049653Application Date: 2019-04-29
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Publication No.: US11332463B2Publication Date: 2022-05-17
- Inventor: Brendan M. Crowley , Brian T. Campbell , Harry R. Chobanian , James I. Fells , Deodial G. Guiadeen , Thomas J. Greshock , Kenneth J. Leavitt , Vanessa L. Rada , Ian M. Bell
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Patricia A. Shatynski; John C. Todaro
- International Application: PCT/US2019/029561 WO 20190429
- International Announcement: WO2019/212927 WO 20191107
- Main IPC: C07D413/08
- IPC: C07D413/08 ; C07D413/14 ; C07D417/08 ; C07D417/14 ; C07D403/08 ; C07D513/04 ; C07D471/04 ; C07D487/04 ; A61P25/00

Abstract:
The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
Public/Granted literature
- US20210070745A1 SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS Public/Granted day:2021-03-11
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