- Patent Title: Modified variable domain molecules and methods for producing them
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Application No.: US16407706Application Date: 2019-05-09
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Publication No.: US11332522B2Publication Date: 2022-05-17
- Inventor: Daniel Christ , Kip Dudgeon , Romain Rouet
- Applicant: GARVAN INSTITUTE OF MEDICAL RESEARCH
- Applicant Address: AU Darlinghurst
- Assignee: GARVAN INSTITUTE OF MEDICAL RESEARCH
- Current Assignee: GARVAN INSTITUTE OF MEDICAL RESEARCH
- Current Assignee Address: AU Darlinghurst
- Agency: Duane Morris LLP
- Agent Thomas J. Kowalski; Deborah L. Lu
- Priority: AU2011901522 20110421,AU2011904856 20111121
- Main IPC: C40B40/10
- IPC: C40B40/10 ; C40B50/06 ; A61K49/00 ; C07K1/22 ; G01N33/53 ; A61K49/04 ; A61K49/14 ; A61K49/16 ; C07K16/18 ; C07K16/24 ; C07K16/32 ; A61K49/22 ; A61K51/08 ; A61K51/10 ; C07K16/40 ; C12N15/10 ; G01N33/543 ; G01N33/574
Abstract:
The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.
Information query
