Invention Grant
- Patent Title: Antibody polypeptides and uses thereof
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Application No.: US15761260Application Date: 2016-10-04
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Publication No.: US11332543B2Publication Date: 2022-05-17
- Inventor: Amanda Thuy Tran , Anders Axelsson , Cecilia Ann-Christin Malmborg Hager , Kjell Sjöström , Sven-Erik Strand , Urpo Juhani Lamminmäki
- Applicant: FREDAX AB
- Applicant Address: SE Bjarred
- Assignee: FREDAX AB
- Current Assignee: FREDAX AB
- Current Assignee Address: SE Bjarred
- Agency: Dann, Dorfman, Herrell & Skillman
- Agent Robert C. Netter, Jr.
- Priority: GB1517550 20151005,GB1519105 20151029
- International Application: PCT/EP2016/073684 WO 20161004
- International Announcement: WO2017/060247 WO 20170413
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/30 ; A61K51/10 ; A61K39/395 ; A61K47/68 ; A61P35/00 ; G01N33/574
Abstract:
The present invention provides antibody polypeptides with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.
Public/Granted literature
- US20180273634A1 ANTIBODY POLYPEPTIDES AND USES THEREOF Public/Granted day:2018-09-27
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