Invention Grant
- Patent Title: Three-dimensional vascular network assembly from induced pluripotent stem cells
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Application No.: US15746477Application Date: 2016-07-21
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Publication No.: US11332717B2Publication Date: 2022-05-17
- Inventor: Sharon Gerecht , Xin Yi Chan , Quinton Smith , Yu-I Shen
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Venable LLP
- Agent Keith G. Haddaway
- International Application: PCT/US2016/043231 WO 20160721
- International Announcement: WO2017/015415 WO 20170126
- Main IPC: C12N5/071
- IPC: C12N5/071 ; A61K9/00 ; A61K9/06 ; A61K47/36 ; A61K47/42 ; A61K35/00 ; A61K35/545 ; A61P31/02 ; A61L27/24
Abstract:
Early vascular cells (EVCs), including endothelial cells and pericytes, are generated from hiPSCs. Unlike the isolated endothelial progenitor cells, the differentiated ECs mature and are functional. When encapsulated in synthetic hydrogel, EVCs respond to matrix cues and self-assembled to form three-dimensional EVCs. Moreover, these EVCs respond to hypoxic microenvironment and undergo vasculogenesis to form complex 3D networks.
Public/Granted literature
- US20180216063A1 THREE-DIMENSIONAL VASCULAR NETWORK ASSEMBLY FROM INDUCED PLURIPOTENT STEM CELLS Public/Granted day:2018-08-02
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