Invention Grant
- Patent Title: Codon optimization for increasing transgene expression in chloroplasts of higher seed plants
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Application No.: US16086416Application Date: 2017-03-20
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Publication No.: US11332754B2Publication Date: 2022-05-17
- Inventor: Henry Daniell
- Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Applicant Address: US PA Philadelphia
- Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee Address: US PA Philadelphia
- Agency: Howson & Howson LLP
- Agent Kathleen D. Rigaut
- International Application: PCT/US2017/023263 WO 20170320
- International Announcement: WO2017/165320 WO 20170928
- Main IPC: C12N15/82
- IPC: C12N15/82 ; C07K14/65 ; C07K14/755 ; A61K39/12 ; A61P31/14 ; A61P1/02 ; A61K9/68 ; C07K14/47 ; C12N7/00 ; C12N9/26 ; A61K39/00
Abstract:
Methods for improving transgene in chloroplasts are disclosed along with improved transgenes so produced and methods of use thereof for the treatment of disease. Specifically, the methods comprising analyzing the native sequence of a nucleic acid encoding a protein of interest and replacing codons in said sequence with those preferentially used in psbA genes in chloroplasts in higher plants.
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