Invention Grant
- Patent Title: Method for the selection of a long-term producing cell using histone acylation as markers
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Application No.: US15311460Application Date: 2015-05-13
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Publication No.: US11332797B2Publication Date: 2022-05-17
- Inventor: Ulrich Goepfert , Peter Becker , Benjamin Moritz
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Nicole Fortune
- Priority: EP14168896 20140519
- International Application: PCT/EP2015/060593 WO 20150513
- International Announcement: WO2015/177022 WO 20151126
- Main IPC: C12Q1/6888
- IPC: C12Q1/6888 ; C12N15/67
Abstract:
Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide.
Public/Granted literature
- US20170081732A1 Method for the Selection of a Long-Term Producing Cell using Histone Acylation as Markers Public/Granted day:2017-03-23
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