The present application discloses a display panel, a display device, and a manufacturing method. The display panel includes a plurality of first pixels and a plurality of second pixels, where a color of each first pixel is different from that of each second pixel; the first pixels are configured as a high domain region, and the second pixels are configured as a low domain region; the number of alignment regions of the high domain region is greater than that of alignment regions of the low domain region; and in the display panel, the number of alignment regions of the pixels of the same row or the same column is the same.