There is provided a method and device for data replication. The method comprises: obtaining, in a network interface card, data segments by segmenting input first data; determining, in the network interface card, fingerprints corresponding to the data segments; and comparing, in a central processing unit, the fingerprints of the data segments with existing fingerprints corresponding to processed data segments, and determining, based on a result of the comparing, whether to de-duplicate the data segments corresponding to the fingerprints, to perform the data replication.