A method and device for processing a transaction request in a blockchain, an apparatus and a medium are provided, which are related to blockchain technology. The method includes: determining at least one transaction request set according to one or more dependency relationships among one or more transaction requests in a blockchain network; and determining a target transaction request set from the at least one transaction request set, to generate a block by performing one or more transaction requests in the target transaction request set. Reasonability of a blockchain node in selecting a transaction request during a block generation process may be improved.