A manufacturing device of a membrane-electrode assembly for a fuel cell is provided. The manufacturing device includes an electrolyte membrane feeding unit forming a first and second ionomer bases impregnated at both surfaces of a reinforcing layer and unwinding an electrolyte membrane wound in a roll type supplied in a predetermined transporting path. A first patterning unit is disposed at a rear side of the electrolyte membrane feeding unit and patterns a first ionomer protrusion pattern layer on the first ionomer base and a second patterning unit is disposed at the rear side of the first patterning unit and patterns a second ionomer protrusion pattern layer on the second ionomer base. A transfer unit is disposed at the rear side of the second patterning unit and couples a catalyst electrode layer on the first and second ionomer protrusion pattern layers by a roll laminating method.