A three dimensional mattress system with environment control is provided which may be configured to provide three dimensional body support to a user. In some embodiments, the system may include a rigid frame that may form a frame cavity. Optionally, the system may include one or more temperature regulators. A plurality of pillows may be positioned within the frame cavity, and a user may be supported by the plurality of pillows. Optionally, one or more air moving devices may be configured to move air external to the frame through the plurality of pillows, and one or more air filters may be configured to filter air moved by the air moving devices.