Invention Grant
- Patent Title: Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation
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Application No.: US16768028Application Date: 2018-11-29
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Publication No.: US11337909B2Publication Date: 2022-05-24
- Inventor: Michael Bader , Fatimunnisa Qadri , Mihail Todiras , Natalia Alenina
- Applicant: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
- Applicant Address: DE Berlin
- Assignee: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
- Current Assignee: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
- Current Assignee Address: DE Berlin
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: EP17204424 20171129
- International Application: PCT/EP2018/082997 WO 20181129
- International Announcement: WO2019/106085 WO 20190606
- Main IPC: A61K8/49
- IPC: A61K8/49 ; A61K8/41 ; A61Q5/08 ; A61Q5/10 ; A61Q17/04 ; A61Q19/02 ; A61Q19/04 ; A61K9/00 ; A61K31/4174 ; A61K45/06 ; A61K8/64 ; A61Q19/00 ; A61P17/00 ; A61K8/35 ; A61K8/40 ; A61K9/70 ; A61K31/655 ; A61K38/34 ; A61P35/00 ; C12N9/48
Abstract:
A cosmetic method for modulating pigmentation in a subject includes administering a modulator of angiotensin-converting enzyme 2 (ACE2 modulator) to the subject. The ACE2 modulator can be an inhibitor of angiotensin-converting enzyme 2 (ACE2 inhibitor), in which case, the ACE2 inhibitor can be administered to increase pigmentation in the subject. The ACE2 modulator can also be an activator of angiotensin-converting enzyme 2 (ACE2 activator), in which case the ACE2 activator can be administered to decrease pigmentation in the subject. The treatment of inflammatory skin disease can also be achieved by inhibition of angiotensin-converting enzyme 2.
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