An antimicrobial strengthened glass and a preparation process thereof. The antimicrobial strengthened glass made from components including 30-50 parts of silicon dioxide, 10-20 parts of epoxy resin, 10-20 parts of titanium dioxide, 5-15 parts of nano bismuth oxide, 8-12 parts of boron oxide, 4-8 parts of chlorinated polyethylene, 2-6 parts of aluminum oxide, 1-3 parts of sodium oxide, 1-3 parts of manganese dioxide, 5-15 parts of graphite powder, 1-3 parts of barium sulfate, 2-4 parts of calcium hexaluminate, 1-3 parts of sodium fluorosilicate, 2-4 parts of borax decahydrate, 3-5 parts of sodium oxalate, 1-2 parts of sodium phosphate, 1-3 parts of sodium carbonate, 1-3 parts of potassium persulfate, 1-2 parts of potassium carbonate, 1-5 parts of ethylenediamine tetraacetic acid disodium, 1-5 parts of acrylamide, 0.01-1 part of silver nitrate and 0.01-1 parts of zinc sulfate.