- Patent Title: Process for the preparation of GalNAc oligonucleotide conjugates
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Application No.: US16939849Application Date: 2020-07-27
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Publication No.: US11339187B2Publication Date: 2022-05-24
- Inventor: Simon Breitler
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agency: Genentech, Inc.
- Agent Kevin M. Clark
- Priority: EP18153875 20180129
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H5/06 ; C07H15/08 ; C07D207/46 ; C07H1/00
Abstract:
The invention comprises a process for the preparation of GalNAc oligonucleotide conjugates which comprises the coupling of a GalNAc cluster compound of the formula or corresponding salts, enantiomers and/or a stereoisomer thereof, with an oligonucleotide in the presence of an O-dicarboximidouronium salt as coupling agent.
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