Invention Grant
- Patent Title: Stable production of virulent enterovirus 71 and use thereof
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Application No.: US16496326Application Date: 2018-03-27
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Publication No.: US11339376B2Publication Date: 2022-05-24
- Inventor: Satoshi Koike , Kyousuke Kobayashi , Yui Sudaka , Ayumi Imura
- Applicant: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
- Applicant Address: JP Tokyo
- Assignee: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
- Current Assignee: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
- Current Assignee Address: JP Tokyo
- Agency: Myers Bigel, P.A.
- Priority: JPJP2017-072562 20170331
- International Application: PCT/JP2018/012410 WO 20180327
- International Announcement: WO2018/181298 WO 20181004
- Main IPC: C12N7/00
- IPC: C12N7/00 ; C12N5/071 ; C12Q1/70 ; G01N33/15
Abstract:
Provided is a host cell for stably propagating a virulent hand, foot and mouth disease virus, the host cell expressing no heparan sulfate and overexpressing primate scavenger receptor class B member 2 (SCARB2). Also provided is a method for screening for an anti-hand, foot and mouth disease virus vaccine or an anti-hand, foot and mouth disease virus drug using a stably cultured virulent hand, foot and mouth disease virus.
Public/Granted literature
- US20200032222A1 STABLE PRODUCTION OF VIRULENT ENTEROVIRUS 71 AND USE THEREOF Public/Granted day:2020-01-30
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