Invention Grant
- Patent Title: Method for the in vivo synthesis of 4-hydroxymethylfurfural and derivatives thereof
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Application No.: US16806728Application Date: 2020-03-02
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Publication No.: US11339414B2Publication Date: 2022-05-24
- Inventor: Paulo Moises Raduan Alexandrino , Iuri Estrada Gouvea , Veronica Leite Queiroz
- Applicant: Braskem S.A.
- Applicant Address: BR Sao Paulo
- Assignee: Braskem S.A.
- Current Assignee: Braskem S.A.
- Current Assignee Address: BR Sao Paulo
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: C12P17/04
- IPC: C12P17/04 ; C07D307/68 ; C12N9/88 ; C12N9/04 ; C12N9/02 ; C12N9/08 ; C12N9/16 ; C12N1/19 ; C12N1/21

Abstract:
The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
Public/Granted literature
- US20200277639A1 METHOD FOR THE IN VIVO SYNTHESIS OF 4-HYDROXYMETHYLFURFURAL AND DERIVATIVES THEREOF Public/Granted day:2020-09-03
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