Invention Grant
- Patent Title: Method for assessing the risk of complications in patients with systemic inflammatory response syndrome (sirs)
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Application No.: US15780573Application Date: 2016-12-01
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Publication No.: US11339438B2Publication Date: 2022-05-24
- Inventor: Elisabeth Cerrato , Benjamin Delwarde , Guillaume Monneret , Estelle Peronnet , Julien Textoris , Fabienne Venet
- Applicant: BIOMERIEUX , HOSPICES CIVILS DE LYON , UNIVERSITE CLAUDE BERNARD LYON 1
- Applicant Address: FR Marcy-l'Etoile; FR Lyons; FR Villeurbanne
- Assignee: BIOMERIEUX,HOSPICES CIVILS DE LYON,UNIVERSITE CLAUDE BERNARD LYON 1
- Current Assignee: BIOMERIEUX,HOSPICES CIVILS DE LYON,UNIVERSITE CLAUDE BERNARD LYON 1
- Current Assignee Address: FR Marcy-l'Etoile; FR Lyons; FR Villeurbanne
- Agency: Ladas & Parry LLP
- Agent Malcolm J. MacDonald
- Priority: FR1561671 20151201
- International Application: PCT/FR2016/053164 WO 20161201
- International Announcement: WO2017/093672 WO 20170608
- Main IPC: C12Q1/6883
- IPC: C12Q1/6883 ; C12Q1/6806 ; C12Q1/686

Abstract:
The invention concerns a method of in vitro or ex vivo evaluation of the risk of complications in a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, the method being characterized in that it comprises the step of detecting, in a biological sample obtained from said patient, at least one transcript of the IL7R gene, as well as measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene, in a biological sample from a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, in order to evaluate the risk of complications, and in particular of mortality, in said patient.
The invention also concerns kits for measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene in a biological sample.
The invention also concerns kits for measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene in a biological sample.
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