A method and system for transporting and/or storing temperature-sensitive materials. In one embodiment, the system may be a hybrid system that includes an active temperature-control system and a passive temperature-control system. The active temperature-control system may be, for example, a portable refrigerator that includes an internal chamber for maintaining contents within a desired temperature range. The passive temperature-control system, which includes at least one phase-change material (PCM) member and space for receiving one or more temperature-sensitive materials, may be removably positioned entirely within the internal chamber of the active temperature-control system. When temperature-sensitive materials are loaded into the passive temperature-control system and the passive temperature-control system is loaded into the active temperature-control system, the active temperature-control system keeps the temperature-sensitive materials within a desired temperature range and charges the PCM members for when the passive temperature-control system is thereafter removed from the active temperature-control system.