Invention Grant
- Patent Title: Universal method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in biological samples
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Application No.: US16082708Application Date: 2017-03-07
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Publication No.: US11340233B2Publication Date: 2022-05-24
- Inventor: Christine Klinguer-Hamour , Marie-Claire Janin-Bussat
- Applicant: PIERRE FABRE MEDICAMENT
- Applicant Address: FR Boulogne-Billancourt
- Assignee: PIERRE FABRE MEDICAMENT
- Current Assignee: PIERRE FABRE MEDICAMENT
- Current Assignee Address: FR Boulogne-Billancourt
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- International Application: PCT/EP2017/055362 WO 20170307
- International Announcement: WO2017/153432 WO 20170914
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N33/543 ; G01N33/577 ; G01N33/94
Abstract:
The present invention relates to a new method for capturing and analysing antibody-drug conjugates (ADCs) in biological samples, such as e.g., serum. Methods for analysing the structure of an antibody-drug conjugate (ADC) in a biological sample and methods for assessing the stability of an ADC are also provided.
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