A detector includes a first detection layer (1141) and a second detector layer (1142). The first and second detection layers include a first and second scintillator (204, 7041) (216, 7042), a first and second active photosensing region (210, 7081) (220, 7082), a first portion (206, 7261) of a first substrate (208, 7061), and a second portion (218, 7262) of a second substrate (208, 7062). An imaging system (100) includes a radiation source (110), a radiation sensitive detector array (108) comprising a plurality of multi-layer detectors (112), and a reconstructor (118) configured to reconstruct an output of the detector array and produces an image. The detector array includes a first detection layer and a second detector layer with a first and second scintillator, a first and second active photosensing region, a first portion of a first substrate, and a second portion of a second substrate.