RFID ICs sense and indicate changes in their surrounding environment, such as changes in temperature, humidity, chemical presence, RF signals, and similar. An RFID IC indicates when a significant environmental change has occurred, for example by adjusting the value of a flag, writing data to memory, transmitting a message to an external entity, exiting a sleep state, and/or responding repeatedly to an inventorying reader. In some cases, RFID IC actively notifies an external entity that a significant environmental change has been sensed. For example, RFID IC may alert the external entity by participating in a special inventory process meant for RFID ICs sending environmental change. The RFID IC may alert the external entity by interjecting itself into an inventory round, re-participating in an inventory round, refraining from entering a sleep state after inventorying, and/or adjusting timing of a scheduled reply to communicate with an RFID reader ahead of schedule.