Invention Grant
- Patent Title: Process for the preparation of the crystalline form III of tipiracil hydrochloride
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Application No.: US16760685Application Date: 2018-10-23
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Publication No.: US11344550B2Publication Date: 2022-05-31
- Inventor: Fabio Morana , Stefano Gobbato , Lucia Cozzi , Jacopo Roletto , Paolo Paissoni
- Applicant: Procos S.P.A.
- Applicant Address: IT Cameri
- Assignee: Procos S.P.A.
- Current Assignee: Procos S.P.A.
- Current Assignee Address: IT Cameri
- Agency: Silvia Salvadori, P.C.
- Agent Silvia Salvadori
- Priority: IT102017000124805 20171102
- International Application: PCT/EP2018/078964 WO 20181023
- International Announcement: WO2019/086292 WO 20190509
- Main IPC: C07D403/06
- IPC: C07D403/06 ; A61K31/513
Abstract:
The present invention concerns a process for the preparation of the crystalline form III of Tipiracil hydrochloride having a content of residual solvents lower than the ICH limits. Said process is advantageous with respect to the known processes because it allows the production of the form III of Tipiracil hydrochloride suitable for use in the preparation of pharmaceutical finished products.
Public/Granted literature
- US20200330465A1 PROCESS FOR THE PREPARATION OF THE CRYSTALLINE FORM III OF TIPIRACIL HYDROCHLORIDE Public/Granted day:2020-10-22
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