Invention Grant
- Patent Title: Short syntheses of (−)-picrotoxinin and related compounds
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Application No.: US16947560Application Date: 2020-08-06
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Publication No.: US11351147B2Publication Date: 2022-06-07
- Inventor: Steven W. M. Crossley , Guanghu Tong , Michael Lambrecht , Ryan Shenvi
- Applicant: The Scripps Research Institute
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Schwegman Lundberg & Woessner, P.A.
- Main IPC: A61K31/365
- IPC: A61K31/365 ; C07D493/18 ; C07D493/22 ; A61P25/00 ; A61K31/366
Abstract:
The present disclosure relates to concise processes for making (−)-picrotoxinin (1, PXN) and 5-methyl-picrotoxinin (20, 5MePXN), and to 5MePXN, its pharmaceutical compositions, and its method of use for inhibiting GABAA receptor.
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