A transport refrigeration system (TRS) includes a first heat transfer circuit including a first compressor, a condenser, a first expansion device, and a cascade heat exchanger. The first compressor, the condenser, the first expansion device, and the cascade heat exchanger are in fluid communication such that a first heat transfer fluid can flow therethrough. The TRS includes a second heat transfer circuit including a second compressor, the cascade heat exchanger, a second expansion device, and an evaporator. The second compressor, the cascade heat exchanger, the second expansion device, and the evaporator are in fluid communication such that a second heat transfer fluid can flow therethrough. The first heat transfer circuit and the second heat transfer circuit are arranged in thermal communication at the cascade heat exchanger such that the first heat transfer fluid and the second heat transfer fluid are in a heat exchange relationship at the cascade heat exchanger.