Invention Grant
- Patent Title: Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
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Application No.: US16098341Application Date: 2017-05-08
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Publication No.: US11352322B2Publication Date: 2022-06-07
- Inventor: Sridharan Rajagopal , Mahanandeesha S. Hallur , Purushottam Dewang , Kannan Murugan , Durga Prasanna Kumar C. H. , Pravin Iyer , Chandrika Mulakala , Dhanalakshmi Sivanandhan , Sreekala Nair , Mohd Zainuddin , Subramanyam Janardhan Tantry , Chandru Gajendran , Sriram Rajagopal
- Applicant: Jubilant Epicore LLC
- Applicant Address: US PA Yardley
- Assignee: Jubilant Epicore LLC
- Current Assignee: Jubilant Epicore LLC
- Current Assignee Address: US PA Yardley
- Agency: Seed IP Law Group LLP
- Priority: IN201641016129 20160509
- International Application: PCT/IN2017/050167 WO 20170508
- International Announcement: WO2017/195216 WO 20171116
- Main IPC: C07D205/12
- IPC: C07D205/12 ; A61P35/00 ; C07C235/56 ; C07C237/20 ; C07C259/08 ; C07D205/04 ; C07D211/26 ; C07D217/18 ; C07D231/12 ; C07D233/64 ; C07D239/26 ; C07D249/04 ; C07D401/04 ; C07D401/14 ; C07D413/12 ; C07D413/14 ; C07D417/06 ; C07D417/12 ; C07D487/04 ; C07D495/04 ; C07D209/44 ; A61K45/06

Abstract:
The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDAC and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, parkinson's disease and the like.
Public/Granted literature
- US20200308110A1 CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS Public/Granted day:2020-10-01
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