Invention Grant
- Patent Title: Salt of fused ring pyrimidine compound, crystal form thereof and preparation method therefor and use thereof
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Application No.: US17058151Application Date: 2019-05-10
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Publication No.: US11352368B2Publication Date: 2022-06-07
- Inventor: Yuguang Wang , Nong Zhang , Pingjing Zhang
- Applicant: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
- Applicant Address: CN Guangdong
- Assignee: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
- Current Assignee: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
- Current Assignee Address: CN Guangdong
- Agency: Houston Beshining Law Office PLLC
- Agent Liangang Ye
- Priority: CN201810551904.1 20180531
- International Application: PCT/CN2019/086373 WO 20190510
- International Announcement: WO2019/228171 WO 20191205
- Main IPC: C07D495/04
- IPC: C07D495/04 ; A61K31/519 ; A61P35/00 ; A61P35/02 ; C07C57/15

Abstract:
Disclosed are a salt of a fused ring pyrimidine compound, a crystal form thereof and a preparation method therefor and the use thereof. The fused ring pyrimidine compound is N-[7-(4-fluoro-2-methoxyphenyl)-6-methylthieno[3,2-d]pyrimidin-2-yl]-1-(piperidin-4-yl)-1H-pyrazol-4-amine, having a structure as shown in formula 1. The preparation methods in the invention for the salt of the fused ring pyrimidine compound and the crystal form thereof are simple; and the salt of the fused ring pyrimidine compound and the crystal form thereof at least have the characteristics of having a better stability, not easily absorbing moisture, being of a polycrystalline type, having a chemical stability and pharmacokinetics, and having an improved solubility.
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