Invention Grant
- Patent Title: Benzimidamides compounds comprising an oxaborinin ring
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Application No.: US16972732Application Date: 2019-06-05
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Publication No.: US11352372B2Publication Date: 2022-06-07
- Inventor: John Liddle , Ann Louise Walker , Gemma Victoria White , Alexis Denis , Nerina Dodic , Marie-Hélène Fouchet , Anne Bouillot
- Applicant: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Applicant Address: FR Paris
- Assignee: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Current Assignee: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Current Assignee Address: FR Paris
- Agency: WCF IP
- Priority: GB1809378 20180607
- International Application: PCT/EP2019/064599 WO 20190605
- International Announcement: WO2019/234075 WO 20191212
- Main IPC: C07F5/02
- IPC: C07F5/02
Abstract:
The invention relates to 4-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-3-yl)benzimidamide derivatives and their use in treating diseases and conditions of the skin (for example, Netherton syndrome, rosacea atopic dermatitis, psoriasis and itch) caused by abnormally high levels of protease activity (particularly of serine proteases such as kallikreins). In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
Public/Granted literature
- US20210253604A1 Novel Benzimidamides Compounds Comprising an Oxaborinin Ring Public/Granted day:2021-08-19
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