Invention Grant
- Patent Title: Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
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Application No.: US16863715Application Date: 2020-04-30
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Publication No.: US11352374B2Publication Date: 2022-06-07
- Inventor: Nin N. Dingra , Theppawut Israsena Na Ayudhya
- Applicant: University of Alaska Anchorage , Florida Southwestern State College , The Research Foundation for the State University of New York
- Applicant Address: US AK Anchorage; US FL Fort Myers; US NY Albany
- Assignee: University of Alaska Anchorage,Florida Southwestern State College,The Research Foundation for the State University of New York
- Current Assignee: University of Alaska Anchorage,Florida Southwestern State College,The Research Foundation for the State University of New York
- Current Assignee Address: US AK Anchorage; US FL Fort Myers; US NY Albany
- Agency: Ballard Spahr LLP
- Main IPC: A61K31/69
- IPC: A61K31/69 ; A61P43/00 ; C07F5/02
Abstract:
Disclosed is a method of delivering therapeutic carbon monoxide to the cells and tissues of a patient which comprises administering thereto a compound of the formula XBY1Y2C(O)V (I) or pharmaceutically acceptable salts thereof. In addition, disclosed is a method of delivering a drug to a diseased cell or tissue by administering a compound of formula I either wherein at least one of X is a drug containing an amino group or V is a drug containing an amino group or hydroxyl group less a hydrogen on the amino or hydroxyl group. Further disclosed are novel compounds of Formula I.
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