Invention Grant
- Patent Title: Engineered PD-1 variants
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Application No.: US16096369Application Date: 2017-05-09
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Publication No.: US11352413B2Publication Date: 2022-06-07
- Inventor: Jonathan R. Lai , Steven Almo , Nina Liu , Julia Frei
- Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE
- Applicant Address: US NY Bronx
- Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
- Current Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
- Current Assignee Address: US NY Bronx
- Agency: Foley Hoag LLP
- International Application: PCT/US2017/031681 WO 20170509
- International Announcement: WO2017/200796 WO 20171123
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; A61P35/00 ; A61K38/16 ; C07K14/735 ; C07K14/47 ; C07K14/705 ; A61P31/00 ; A61K38/17 ; C12N15/62
Abstract:
Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD-L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.
Public/Granted literature
- US20190127439A1 ENGINEERED PD-1 VARIANTS Public/Granted day:2019-05-02
Information query
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