Invention Grant
- Patent Title: Genetic engineering of non-human animals for the production of chimeric antibodies
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Application No.: US15463752Application Date: 2017-03-20
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Publication No.: US11352444B2Publication Date: 2022-06-07
- Inventor: Larry Green , Hiroaki Shizuya
- Applicant: ABLEXIS, LLC
- Applicant Address: US CA San Diego
- Assignee: ABLEXIS, LLC
- Current Assignee: ABLEXIS, LLC
- Current Assignee Address: US CA San Diego
- Agency: Haley Guiliano LLP
- Agent James F. Haley, Jr.; Brian M. Gummow
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; C07K16/46 ; A01K67/027 ; C07K16/18 ; C12N15/85
Abstract:
The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
Public/Granted literature
- US20170188557A1 GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES Public/Granted day:2017-07-06
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