Invention Grant
- Patent Title: Genomic engineering of pluripotent cells
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Application No.: US16656484Application Date: 2019-10-17
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Publication No.: US11352607B2Publication Date: 2022-06-07
- Inventor: Bahram Valamehr , Ramzey Abujarour , Tom Tong Lee , Weijie Lan , Raedun Clarke , Ryan Bjordahl
- Applicant: Fate Therapeutics, Inc.
- Applicant Address: US CA San Diego
- Assignee: Fate Therapeutics, Inc.
- Current Assignee: Fate Therapeutics, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Greenberg Traurig, LLP
- Main IPC: C12N5/074
- IPC: C12N5/074 ; C12N15/90 ; C12N5/0783 ; A61P35/02 ; C07K16/28 ; A61P35/00 ; C12N5/078 ; C12N15/85 ; A61K35/17 ; C07K14/705 ; C07K14/725 ; C12N9/22 ; C12N15/11 ; C12N15/113 ; A61K35/12
Abstract:
Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites. Also provided are cell populations or clonal cell lines derived from genome-engineered iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or in/dels in one or more selected endogenous genes.
Public/Granted literature
- US20200095604A1 GENOMIC ENGINEERING OF PLURIPOTENT CELLS Public/Granted day:2020-03-26
Information query
