Invention Grant
- Patent Title: Minimal UTR sequences
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Application No.: US16090588Application Date: 2017-03-30
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Publication No.: US11352638B2Publication Date: 2022-06-07
- Inventor: Christian Plank , Carsten Rudolph , Manish Kumar Aneja , Ludwig Weiss
- Applicant: ethris GmbH
- Applicant Address: DE Planegg
- Assignee: ethris GmbH
- Current Assignee: ethris GmbH
- Current Assignee Address: DE Planegg
- Agency: Morse, Barnes-Brown & Pendleton, P.C.
- Agent Lisa M. Warren, Esq.; Erin E. Bryan, Esq.
- Priority: EP16163264 20160331,EP16177094 20160630
- International Application: PCT/EP2017/057592 WO 20170330
- International Announcement: WO2017/167910 WO 20171005
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/85 ; C12N15/67 ; C12N5/071

Abstract:
Described are DNA molecules which can be transcribed into an mRNA harbouring novel UTR sequences combining the advantages of being extremely short and at the same time allowing for high translation efficiencies of RNA molecules containing them. Further, described are vectors comprising such a DNA molecule and to host cells comprising such a vector. Moreover, described are corresponding RNA molecules containing such UTRs. Further, described in a pharmaceutical composition comprising the described RNA molecule are optionally a pharmaceutically acceptable carrier as well as to the use of the described UTRs for translating a coding region of an RNA molecule into a polypeptide or a protein encoded by said coding region.
Public/Granted literature
- US20190144883A1 NOVEL MINIMAL UTR SEQUENCES Public/Granted day:2019-05-16
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