Invention Grant
- Patent Title: Compositions and methods for treating Leber's hereditary optic neuropathy
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Application No.: US17181849Application Date: 2021-02-22
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Publication No.: US11352645B2Publication Date: 2022-06-07
- Inventor: Bin Li
- Applicant: WUHAN NEUROPHTH BIOTECHNOLOGY LIMITED COMPANY
- Applicant Address: CN Hubei
- Assignee: WUHAN NEUROPHTH BIOTECHNOLOGY LIMITED COMPANY
- Current Assignee: WUHAN NEUROPHTH BIOTECHNOLOGY LIMITED COMPANY
- Current Assignee Address: CN Hubei
- Agency: Cooley LLP
- Priority: CN201810948193.1 20180820,WOPCT/CN2018/103937 20180904,CN201811221305.X 20181019,CN201811230856.2 20181022,WOPCT/CN2018/113799 20181102,WOPCT/CN2018/118662 20181130,WOPCT/CN2019/070461 20190104
- Main IPC: C12N15/86
- IPC: C12N15/86 ; A61K31/56 ; A61K45/06 ; A61P27/02 ; A61K48/00
Abstract:
Disclosed herein is a recombinant nucleic acid, comprising: a mitochondrial targeting sequence; a mitochondrial protein coding sequence, wherein said mitochondrial protein coding sequence encodes a polypeptide comprising a mitochondrial protein; and a 3′UTR nucleic acid sequence. Also disclosed is a pharmaceutical composition comprising the recombinant nucleic acid and a method of treating Leber's hereditary optic neuropathy (LHON) using the pharmaceutical composition.
Public/Granted literature
- US20210189429A1 COMPOSITIONS AND METHODS FOR TREATING LEBER'S HEREDITARY OPTIC NEUROPATHY Public/Granted day:2021-06-24
Information query
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