A facade panel screw for the optimized fastening of facade panel elements on a substructure has a head with very large diameter DK, a substantially cylinder cross-sectional shaft, which is at least partially provided with a thread (nominal diameter DS) and a conical tip comprising a tip angle γ. The thread extends continuously from the shaft to the tip. It is characterizing that the tip angle γ is 45°+/−10°, the thread is embodied at least in a two-threaded manner, the head diameter DK is embodied at least twice as large as the nominal diameter DS; and the facade panel screw does not have a drill tip. Such a facade panel screw is used in a fastening arrangement, which comprises a load-bearing component (substructure) and a facade panel. Due to its design, the facade panel screw is able to simplify the fastening of the facade panel and to at least partially correct an inclined positioning in response to the installation.