Methods, system, and computer readable medium are presented for predicting defects using a machine learning component based on a generated signature. A trained machine learning component that has been trained with historic data that represents a series of events that occurred within a plurality of heterogeneous systems over a plurality of periods of change for the heterogeneous systems can be received. A base signature for a first heterogeneous system that includes a first mix of modules can be compared to a current signature for the first heterogeneous system to identify one or more irregularities. The trained machine learning component can predict one or more defects for the first heterogeneous system based on the identified irregularity.