Systems and methods for intelligent computation acceleration transform to allow applications to be executed by accelerated processing units such as graphic processing units (GPUs) or field programmable gate arrays (FPGAs) are disclosed. In an embodiment, a computational profile is generated for an application based on execution metrics of the application for the CPU and the accelerated processing unit, and a genetic algorithm (GA) prediction model is applied to predict execution speedup on an accelerated processing unit for the application. In an embodiment, upon identification of speedup, computational steps are arbitrated among various processing units according to compute availability to achieve optimal completion time for the compute job.