The present disclosure provides a pixel compensation driving circuit, which compensates an actual threshold voltage of a driving transistor, and finally makes current flowing through a light-emitting element independent from the actual threshold voltage of the driving transistor, thereby eliminating a drift of the actual threshold voltage of the driving transistor which causes uneven display of a display device, and improving display effect of a screen. The present disclosure also provides a pixel compensation driving method for driving the pixel compensation driving circuit, and a display device including the pixel compensation driving circuit.