The present disclosure discloses a display panel driving method, a driving system and a display device, includes steps: receiving the first color signals, converting the first color signals into the first color space signals; obtaining a current color saturation signal, determining whether the current color saturation signal is in an adjusting color adjustment interval, if the current color saturation signal is in the adjusting color adjustment interval, obtaining the predetermined adjustment coefficients; adjusting and processing the current color saturation signal to receive a second color space signals; converting the second color space signals into the second color signals in the RGB system to drive a display pane.