Embodiments of the present disclosure provide a voice smart device wake-up method, apparatus, device and storage medium. The method includes: receiving, by a master control device, a wake-up message sent by each smart device, the wake-up message comprising at least sound characteristics information, determining, by the master control device, a target smart device to be woken up according to the sound characteristics information, and sending, by the master control device, a wake-up instruction to the target smart device to be woken up, to wake up the target smart device to be woken up for responding to a voice request from a user. In a case where a plurality of smart devices share a same wake-up word, only one most suitable smart device is waken up to respond to a voice request of the user each time.