Methods and systems for Acknowledgement (ACK)/Negative Acknowledgement (NACK) transmission strategies are provided. According to one aspect, a method of operation of a radio node comprises determining whether a combination of resources for a plurality of signals or channels fulfills a predefined criteria: if so, the plurality of signals or channels are transmitted according to a first transmission strategy in which each signal or channel is transmitted on its respective resource or resources; if not, at least some of the plurality of signals or channels are transmitted according to a second transmission strategy different from the first transmission strategy, e.g., transmitting only a subset of the signals or channels, combining signals and channels, etc. The predefined criteria may be based on the characteristics of the resources for the plurality of signals or channels, such as their locations, bandwidths, signal qualities, relative separation in the frequency domain, or other characteristics.