Invention Grant
- Patent Title: Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of calcium-activated chloride channel TMEM16A
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Application No.: US16606200Application Date: 2018-04-17
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Publication No.: US11358947B2Publication Date: 2022-06-14
- Inventor: Marc O. Anderson , Alan S. Verkman , Puay Wah Phuan
- Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Marc O. Anderson
- Applicant Address: US CA Oakland; US CA San Francisco
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,Marc O. Anderson
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,Marc O. Anderson
- Current Assignee Address: US CA Oakland; US CA San Francisco
- Agency: Seed IP Law Group LLP
- International Application: PCT/US2018/028039 WO 20180417
- International Announcement: WO2018/195127 WO 20181025
- Main IPC: C07D333/80
- IPC: C07D333/80 ; A61P9/12 ; A61P35/00 ; C07D333/68 ; C07D333/78 ; C07D495/04
Abstract:
Provided herein are inhibitors of transmembrane protein 16A (TMEM 16A), a Ca2+-activated CI″ channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment or management of disorders of epithelial fluid and mucus secretion, hypertension, some cancers, pain, and other diseases.
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