Invention Grant
- Patent Title: Pyrazol-3-ones that activate pro-apoptotic BAX
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Application No.: US17064225Application Date: 2020-10-06
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Publication No.: US11358960B2Publication Date: 2022-06-14
- Inventor: Loren D. Walensky , Evripidis Gavathiotis
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: C07D417/04
- IPC: C07D417/04 ; A61P35/00 ; C07D403/14 ; C07D417/14 ; C07D403/04 ; A61K31/4155 ; A61K31/4178 ; A61K31/427 ; A61K31/497 ; C07D413/04
Abstract:
This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).
Public/Granted literature
- US20210032234A1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX Public/Granted day:2021-02-04
Information query
